Line Hotel sits on a quiet backstreet in District 1, the central district of Ho Chi Minh City, a short walk from the busier streets around it. Cafés, bars and restaurants line the nearby lanes: Happy Bar, Rooster Beers and the restaurant Quán Cà Phê Black & White are each 50 m from the hotel. The Bui Vien walking street, the best-known street of the backpacker quarter, is nearby, and Ben Thanh Market, a covered central market, is 1000 m away. Rooms facing the inside of the building are the quieter option, away from the bar music on the street.
Saigon Railway Station is 2.2 km away and Tan Son Nhat International Airport is 5.4 km away, so both can be reached by taxi or ride-hailing car. Ben Thanh Station, on Metro Line 1, is 850 m from the hotel, and the Bến xe Sài Gòn bus station is 200 m away. The hotel has no parking, so guests who arrive by car need to arrange a space nearby.
For museums and parks, the Ho Chi Minh City Fine Arts Museum is 950 m away and September 23 Park is 450 m. Đình Ông Quan Thánh, a traditional communal temple, is 150 m from the hotel, and Thai Binh Market is 200 m away. The museum, the park and Ben Thanh Market are close enough to cover on foot in one outing. At night, Bui Vien is the main draw, with bars, music and street food along the walking street.